Z-Drugs Vs Benzodiazepines

These Z-drugs were made with a better, more improved, pharmacokinetic and pharmacodynamic profile compared to the traditional sleeping tablets on the market.  

Further to this, all  Z-drugs act by binding to the GABA receptor complex; like most familiar benzodiazepine drugs [9].

Having said that, there is a similarity that exists between the Z-drugs and benzodiazepine drugs; that is, they both have a very similar mode of action on GABA receptors [9]. 

Interestingly, zopiclone has a chemical structure to other Z-drugs (see below), such as zolpidem and other central nervous system (CNS) depressants [9]. 



[1] https://www.tandfonline.com/doi/abs/10.1080/13803395.2014.928268

[2] https://www.ncbi.nlm.nih.gov/pubmed/28865038

[3] https://www.ncbi.nlm.nih.gov/pubmed/30722037  

[4] https://www.progressnp.com/article/z-hypnotics-versus-benzodiazepines-for-the-treatment-of-insomnia/

[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2418994/pdf/bjgp58-417.pdf 

[6] https://www.bmj.com/content/345/bmj.e8343

[7] https://onlinelibrary.wiley.com/doi/pdf/10.1002/psb.1061  

[8] https://www.ncbi.nlm.nih.gov/pubmed/12751920  

[9] https://www.ncbi.nlm.nih.gov/pubmed/9506247  

[10] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2418994/pdf/bjgp58-417.pdf

[11] https://www.ncbi.nlm.nih.gov/pubmed/9834048  

[12] https://onlinelibrary.wiley.com/doi/pdf/10.1002/psb.1061

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